Beilstein J. Org. Chem.2019,15, 2191–2203, doi:10.3762/bjoc.15.216
of them being the marine-adapted fungal strain Heydenia cf. alpina. The latter produced two new terpenoids, which are the first secondary metabolites from this genus.
Keywords: FIND; fungalone-stepisolationdevice; Heydenia cf. alpina; natural products; terpenes; Introduction
Natural products
laboratory [4]. E. terrae produced a novel antibiotic called teixobactin with no detectable resistance, as it interacts with key functions of cell wall synthesis that do not undergo fast evolutionary changes [5].
Inspired by this approach we developed the Fungalone-stepIsolatioNDevice (FIND), in order to
Benjamin Libor Henrik Harms Stefan Kehraus Ekaterina Egereva Max Crusemann Gabriele M. Konig Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany 10.3762/bjoc.15.216 Abstract Fungi are an important source of bioactive metabolites. The Fungalone-step
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Graphical Abstract
Scheme 1:
Design and functional parts of the FIND technology.